Genes, lipids and cardiovascular diseases: nutrigenomics and nutrigenetics
Cardiovascular diseases (CVD) are the most frequent cause of death worldwide
and one of the most widely spread causes of morbidity in Western countries.
There is a clustering of CVD in families or in population subgroups, which
suggests that some individuals are at greater risk than others. Clinicians already
take this into account, by considering the family and personal history of their
patients as possible specific risk factors, which can increase significantly the
probability of developing CVD. Susceptibility to atherosclerosis is determined
by a combination of genetic and environmental factors, including diet. Genetic
factors may modify the effects of lifestyle changes on lipid, glucose and energy
metabolism, and subjects with different genotypes may respond differently to
changes in diet and exercise.