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Sciences des Aliments

0240-8813
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An international journal of food science and technology
 

 ARTICLE VOL 22/4 - 2002  - pp.425-430  - doi:10.3166/sda.22.425-430
TITLE
Lactose maldigestion vs. intolerance

ABSTRACT

Lactose maldigestion can be defined as the incomplete digestion of lactose in the small intestine, with some lactose reaching the large intestine/colon. Maldigestion is due to a greater concentration of substrate (lactose) relative to the activity of the mammalian lactase enzyme (lactase). There is a fairly linear relationship between dietary intake and maldigestion under controlled conditions where lactose is consumed alone or in milk. Most of the scientific evidence supports the view that lactase enzyme activity is regulated primarily by genetics in healthy individuals. Further, substantial evidence supports the view that lactase activity falls from infantile levels to adult levels (a 10-20 fold reduction) between the ages of 3 and 5 years in 75% of the World’s population. The loss of intestinal lactase activity is a typical mammalian trait and has been well characterized in a number of species. The temporary loss of intestinal lactase due to malnutrition, alcoholism or other diseases can be an important contributor to maldigestion. Lactose maldigestion is also common among infants, despite their high levels of intestinal lactase activity.

AUTEUR(S)
Dennis A. SAVAIANO

CITATIONS
sda.revuesonline.com/revues/3/citation/909.html

LANGUE DE L'ARTICLE
Anglais

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